Package: methylclock
Type: Package
Title: Methylclock - DNA methylation-based clocks
Version: 1.17.0
Authors@R: c( person("Dolors", "Pelegri-Siso", , "dolors.pelegri@isglobal.org", 
                      role = c("aut", "cre"), 
                      comment = c(ORCID = "0000-0002-5993-3003")),
              person("Juan R.", "Gonzalez", ,"juanr.gonzalez@isglobal.org", 
                     role = c("aut"), 
                     comment = c(ORCID = "0000-0003-3267-2146"))
              )
Description: This package allows to estimate chronological and gestational DNA methylation
       (DNAm) age as well as biological age using different methylation clocks.
       Chronological DNAm age (in years) : Horvath's clock, Hannum's clock, BNN, 
       Horvath's skin+blood clock, PedBE clock and Wu's clock.
       Gestational DNAm age : Knight's clock, Bohlin's clock, Mayne's clock and Lee's clocks.
       Biological DNAm clocks : Levine's clock and Telomere Length's clock.
biocViews: 
  DNAMethylation,
  BiologicalQuestion,
  Preprocessing,
  StatisticalMethod,
  Normalization
License: MIT + file LICENSE
Depends: 
  R (>= 4.1.0),
  methylclockData,
  devtools,
  quadprog
Imports: 
  Rcpp (>= 1.0.6),
  ExperimentHub,
  dplyr, 
  impute, 
  PerformanceAnalytics,
  Biobase,
  ggpmisc,
  tidyverse,
  ggplot2, 
  ggpubr, 
  minfi, 
  tibble,
  RPMM,
  stats,
  graphics,
  tidyr,
  gridExtra,
  preprocessCore,
  dynamicTreeCut,
  planet
Suggests: 
    BiocStyle,
    knitr,
    GEOquery,
    rmarkdown
LinkingTo: Rcpp
Encoding: UTF-8
RoxygenNote: 7.1.2
URL: https://github.com/isglobal-brge/methylclock
BugReports: https://github.com/isglobal-brge/methylclock/issues
VignetteBuilder: knitr
git_url: https://git.bioconductor.org/packages/methylclock
git_branch: devel
git_last_commit: 33c0153
git_last_commit_date: 2025-10-29
Repository: Bioconductor 3.23
