Differential co-expression analysis methods

These functions are used to perform a differential co-expression analysis on experimental data with binary conditions.

dcMethods()

Get names of differential co-expression methods

dcScore()

Compute scores from differential association analysis

dcTest()

Statistical test for differential association analysis

dcAdjust()

Adjust for multiple testing in differential association analysis

dcNetwork()

Generate a differential network from a DC analysis

Functions to evaluate DC methods

These functions are used to evaluate methods implemented in the package and novel methods on simulated data. Expression data is simulated for two conditions, wild-type and knock-down of given genes.

sim102

Simulated expression data with knock-outs

getSimData() getConditionNames() getTrueNetwork()

Get data and conditions from a given knock-down (KD)

plotSimNetwork()

Plot source and true differential networks from simulations

dcPipeline()

Run a DC pipeline on a simulation

dcEvaluate()

Evaluate performance of DC methods on simulations

Additional general use functions

These are functions used in the package but have further uses in general

cor.pairs()

Fast pairwise correlation estimation

mi.ap()

Mutual information using adaptive partitioning

perfMethods()

Get names of performance metric methods

performanceMeasure()

Performance metrics to evaluate classification